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Brain targeting is a difficult task due to various factors; those factors can restrict the entry of drugs into the brain, in the present study polymer-lipid hybrid nanoparticles were prepared for targeting carbamazepine into the brain through the intranasal route. Five formulations were successfully prepared using chitosan, stearic acid and glyceryl mono stearate in different ratio. The particles size were found between 78.88-790nm, the poly dispersibility index were found in the range of 0.273-0.531, the zeta potential were found to be -7.1, -11.6, 22.3 for HN1, HN2, HN3 respectively and for formulation HN4 and HN5 it was found as +12.1 and +22.3. The entrapment efficiency of all the formulations was found between 62.66-88.31%, the in-vitro releases were found in the range of 40-72%. The in-vivo studies were performed on Wister rats. Formulation HN5 containing higher conc. of chitosan has shown high drug targeting efficiency. The lipid-polymer hybrid nanoparticles have shown the possibility of targeting the brain through intranasal delivery. Keywords : polymer-lipid hybrid Nanoparticles, carbamazepine, brain targeting, chitosan

POLYMER -LIPID HYBRID NANOPARTICLES FOR BRAIN TARGETING THROUGH INTRANASAL DELIVERY