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The present study deals with the development and evaluation of controlled porosity osmotic pump (CPOP) tablets of zidovudine-lamivudine. Wet granulation method was used for the development of core tablets. Core tablets were incorporated with HPMCE5 LV polymer, different concentrations of fructose as osmogen and additives. The CPOP tablets were coated with cellulose acetate as a wall forming material, polyethylene glycol as flux regulating agent, and sorbitol acts as pore forming material in SPM. The formulated tablets were evaluated for FTIR, DSC, pre-compression parameters, post compression parameters, in vitro drug release study and scanning electron microscopy study. The optimized formulation had no significant effect on the p H and agitation intensity, but depends on the osmotic pressure of dissolution media indicated that mechanism of drug release. SEM images revealed that no pores were found before dissolution and after dissolution had shown the porous nature of the membrane. Short term stability study at 40±2oC /75±5% RH for the months on the CF4 formulation indicated that there was no significant change weight variation, % friability, drug content and in vitro drug release. Keywords: HPMCE5LV, wet granulation, CPOP, in vitro drug release, stability study .

FORMULATION AND EVALUATION OF CONTROLLED POROSITY OSMOTIC PUMP TABLETS FOR ZIDOVUDINE AND LAMIVUDINE COMBINATION USING FRUCTOSE AS OSMOGEN