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Stevioside is a non-caloric sweetener and used as the alternative to sugar in many countries. It has been reported to have promising antidiabetic activity. In the present investigation, we have developed a multi-particulate system of stevioside consisting of nonpareil pellets for antidiabetic patients. The drug loading on pellets was performed by solvent evaporation and suspension layering method. The loaded pellets were evaluated for yield (%), drug loading efficiency (%), flow properties and in-vitro dissolution study. The stevioside loaded pellets (STL 4) showed yields (92.36%), drug loading efficiency (86.60%), friability (0.74%), drug release (98.31%) within 60 min and good flow properties. The in vivo study indicates the significant reduction in blood glucose levels in alloxan induced diabetic rats after administration of stevioside loaded formulation (STL 4). The developed formulation of stevioside pellets can find its dual applications as a sugar substitute having the potential anti-hyperglycemic effect which can be given easily and safely to the diabetic patients. Keywords: Stevioside; pellets; non-caloric sweetener; anti-hyperglycemic; diabetes.

DEVELOPMENT OF STEVIOSIDE LOADED PELLETS FOR REGULATING THE BLOOD GLUCOSE LEVEL IN DIABETES: IN VIVO- IN VITRO CHARACTERIZATION