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Osteoporosis affects millions of people, especially the aged population and numerous researchers focus on developing novel pharmacotherapeutic agents for the prevention and treatment of osteoporosis. Animal models have become an indispensable part of the pre-clinical assessment of osteoporotic therapeutics and rat models have been widely preferred. The majority of studies so far reported have used young or short-term induced rat models, but they do not mimic the pathological condition in senile osteoporosis. Hence this study has focused on developing an ovariectomised and long term induced (OLI) aged rat model for the preclinical assessment studies. Long term osteoporosis was induced in Wistar rats by ovariectomy followed by the maintenance period of 10 months. Histological evaluation and Micro-CT analysis substantiated the extensive bone loss in the OLI rats compared to Control and ovariectomised and short term induced (OSI) rat model. OLI rats also exhibited impairment in the healing of 3 x 1.5 mm femoral cortical bone defect even after 8 weeks of surgery. Histomorphometric analyses indicated that OLI rats exhibited a poor regeneration efficiency (RE) ratio of 0.67 Â± 0.2 compared to 0.95 Â± 0.1 in the Control group. Chronic bone loss in the OLI rats together with the impaired osteogenic efficacy has been successfully demonstrated which proposes OLI rat models to be utilized for investigating novel pharmacotherapyâ€™s or novel biomaterials intended for osteoporotic applications. Keywords: Osteoporosis, Rat osteoporotic model, long-term osteoporosis induction, oestrogen deficiency.Â  Â

OVARIECTOMISED AND LONG TERM INDUCED (OLI) RAT MODEL FOR PRECLINICAL ASSESSMENT OF OSTEOPOROTIC THERAPEUTICS.