English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Nanoparticles mediated oral drug delivery system has attracted great attention in pharmacology to attain improved therapeutic index of chemotherapeutic drugs. In the present study, naringenin (NRG) - loaded gastroretentive mucoadhesive polymeric nanoparticles has been designed and investigated its application in oral drug delivery system. Naringenin loaded polymeric nanoparticles (NMPN) were prepared by thermal decomposition mediated nanoprecipitation method. Formulated NMPN were characterized and investigated for its mucoadhesive properties by swelling and in vitro mucoadhesion studies. The results indicated that the formulated NPMN were in the size of 66±7nm by dynamic light scattering analysis and the maximum drug loading efficiency was observed around 94.6±0.28%. Further the drug release studies showed that NMPN exhibited sustained drug release in stimulated gastric fluid (SGF; pH=1.2). Pharmacokinetic studies revealed that the formulated NMPN are highly biocompatible and showed enhanced therapeutic efficacy compared to free naringenin. The overall findings demonstrated that the gastroretentive mucoadhesive polymeric nanoparticles can act as a promising candidate with gastroprotective applications in biomedical research.

journal of drug delivery and therapeutics

FORMULATION, CHARACTERIZATION AND PHARMACOKINETIC EVALUATION OF NARINGENIN- LOADED GASTRORETENTIVE MUCOADHESIVE POLYMERIC NANOSYSTEM FOR ORAL DRUG DELIVERY