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Objective: To compare the therapeutic efficacy, compliance & cost effectiveness of single high dose of oral fluconazole with topical clotrimazole in patient with pityriasis versicolor Method: A total number of 60 patients were enrolled for the study. The patients were randomized and allotted into two groups with thirty patients in each groups. The groups were named as GROUP A and GROUP B .All the patient in Group A were treated by applying clotrimazole ointment twice a day for a continuous period of two weeks. This group served as the CONTROL group while patients in GROUP B were treated with single dose of oral fluconazole 400mg.This group served as the STUDY group and the results of this group was compared with the control group. Results: Sixty patients completed the study..There was statistically significant improvement in clinical and mycological assessment in oral fluconazole group with p value of<0.001) Conclusion: Cure rate was higher with oral fluconazole as assessed by clinical & mycological assessments. No side effect was found with single high dose of oral fluconazole.ore economical compared with that of two week regimen of topical therapy. Patient’s compliance also more as it is of single oral therapy. Key words: Pityriasis versicolor,clotrimazole,fluconazole

COMPARATIVE STUDY OF SINGLE HIGH DOSE ORAL FLUCONAZOLE WITH TOPICAL CLOTRIMAZOLE IN PATIENT WITH LOCALISED PITYRIASIS VERSICOLOR