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To have handy reference as source of outstanding knowledge for scientist engaged in developing nanocarrier based oral delivery system of macromolecules (NBODSM). Macromolecule based biopharmaceuticals (proteins, peptides, monoclonal antibodies, and vaccines) explored for delivering associated proclaimed benefits, in diverse domain. Interest evoke for synergising their effect by amalgamating nanotechnology and presenting them as oral delivery system. Diverse methods and technology devised to achieve goal. All of them abreast increasing efficacy, specificity, tolerability and therapeutic index, and minimising toxicities. Each and every system has its own limitation and superiority over others. Amongst them nanocarrier based systems receiving attentions. These systems provide improved performance, stability, and patient compliance, and have potential for improved marketability. Their design and development progressed to make best formula through method of optimisation. This considered being a state of art involves multidisciplinary activity and creates difficulties as several causes needed to be achievable, associated with many features. Available literatures are unable to provide insight on issues relating their development while some are unhandy. In this regard, information collected from databases and presented as a handy note. This insight features on issues relating development of NBODSM and has applicability in product evolution. Presented information will be a helping hand and will offer an outstanding knowledge to developers, while designing them with excellent feature.

NANOCARRIERS IN ORAL DELIVERY OF MACROMOLECULES: UPDATED INSIGHT