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Objective : To compare the local anaesthetic action of central neuron sodium channel blockers Phenytoin Sodium, Sodium Valproate and Carbamazepine with peripheral neuron sodium channel blockers Lignocaine using Infiltration anaesthesia in guinea pigs Material and Methods: In the present study,the local anaesthetic effect of Lignocaine with concentration of 0.2%, 0.1% ,0.05% was compared with Phenytoin Sodium, Sodium Valproate and Carbamazepine in concentrations of 0.2%, 0.1% ,0.05% using different dilutions of  0.05N,0.1N,0.2N HCL  in guinea pig by pricking on the skin produces a squeak or  movement  indicating pain is produced. Results : The results of our present study suggest onset of local anaesthesia with lignocaine 0.2% is significantly fast when compared with concentration of 0.1%, and 0.05% indicating it has better efficacy  when  using for various   local anaesthetic  procedures. In addition onset of local anaesthesia with Phenytoin sodium concentrations of 0.2%, 0.1% ,0.05%  is fast  when compared with Sodium valproate concentrations of 0.2%, 0.1% ,0.05%  and  Carbamazepine concentrations 0.2%, 0.1% ,0.05%. Conclusion: Among antiepileptic drugs with local anaesthesia and  membrane stabilizing activity Phenytoin sodium showed fast on set of action when compared with sodium valproate and Carbamazepine indicating it has better efficacy. Keywords : Local Anaesthetics, Membrane Stabilizing, Infiltration anaesthesia.

COMPARISION OF LOCAL ANAESTHETIC POTENTIALS OF DRUGS HAVING MEMBRANE STABILIZING EFFECT ON INFILTRATION ANAESTHESIA IN GUINEA PIGS