English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The aim of this present work was to improve the dissolution profile of Rifapentine (RPT) using solid dispersions technique with PVP K-30 or HPMC as the carrier, in different ratios of 1:1, 1:2, 1:3, 1:4, 1:5 by the kneading method and solvent evaporation method. For the purpose of comparison, another formulation was prepared by the method of physical mixture with the drug and carrier weight ratios of same. The prepared solid dispersions (SDs) were optimized on the basis of evaluation of Solubility, Drug Release rate and % drug content. Optimized formulation is than characterized by Fourier Transform Infrared Spectroscopy (FTIR), Powder X-ray Diffraction (XRD), Differential Scanning Calorimetry (DSC), Particle size analysis and Scanning Electron Microscopy (SEM) in order to ascertain any physicochemical interactions between the drug and carrier that could affect the dissolution profile of the drug. The dissolution studies were conducted for pure RPT and all the formulated solid dispersions. All the solid dispersions prepared by kneading method and solvent evaporation method showed an enhanced dissolution profile of Rifapentine, as compared to that of pure drug alone but among them all the solid dispersion prepared with PVP-K30 by solvent evaporation method in 1:3 ratio showed better enhancement of solubility and dissolution rate.

AN APPROACH TO ENHANCE THE SOLUBILITY OF RIFAPENTINE BY SOLID DISPERSION TECHNIQUE USING HYDROPHILIC CARRIERS