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The aim of the research work was to isolate a novel bio material from the seeds of Buchanania Lanzan and to evaluate its bio stabilizing ability by various formulating various zidovudine micro emulsions using sunflower oil as oil phase and bio material as bio emulsifier. The bio material was isolated from the seeds of Buchanania Lanzan by simplified economical method. Three different zidovudine micro emulsions were formulated using the bio emulsifier in different concentrations. The formulated micro emulsions were subjected to various evaluation parameters like globule size, ph effect of centrifugation , viscosity, surface tension and invitro drug release. The formulated micro emulsions exhibit uniform globule size, promising stability against centrifugation effect in comparison to standard emulsion. The drug release studies from the formulated micro emulsions exhibited a promising transparency, stability, uniform globule size and shape, surface tension for a period of 24 hrs. Finally the conclusion was drawn that the isolated bio emulsifier acts as novel emulsifier for formulating various drug loaded micro emulsions.

FORMULATION AND EVALUATION OF ZIDOVUDINE NANOSUSPENSIONS USING A NOVEL BIO POLYMER FROM THE SEEDS OF BUCHANANIA LANZAN