English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background: Imipramine is a tricyclic anti depressant drug.  Alprazolam is a benzodiazepine sedative drug, but it has also antidepressive action. Voltage gated calcium channel blockers are well known antihypertensive, anti anginal, anti arrhythmic drugs. Objective: In this study I explored the effects of calcium channel antagonists on the antidepressant action of alprazolam and imipramine. Materials And Methods : Despair swim test model was used to study the anti depressive effect on the Male Sprague-Dawley rats. Rats were divided into nine groups (n = 6 per group). One group received a single dose of Tween 80 solution, as because it was used as vehicle for all the drugs; two groups each received a single dose of the antidepressant alone (alprazolam or imipramine); two groups each received a single dose of the calcium channel blocker (nifedipine or verapamil); four groups each received a single dose of the calcium channel blocker followed by a single dose of the antidepressant (with same doses used for either in the previous four groups). Drug administration was performed concurrently on the nine groups. Results: The anti depressant action of both imipramine and alprazolam was confirmed by this study. . Both verapamil & nifedipine delays the onset of immobility, when administered separately. Verapamil potentiate the antidepressive effect of both imipramine & alprazolam.  When nifedipine was combined with imipramine , there was delay in the onset of immobility and was greater than their single use. . Either imipramine or nifedipine produced a delay in the onset of immobility of 75% and 81%, respectively, compared to the control( p< 0.05) and combining nifedipine with imipramine led to a delay of 73% in the onset of immobility compared to the control ( p< 0.05). Conclusion: Combination of voltage gated calcium channel blocker with imipramine and alprazolam was some positive effect on the antidepressant action. Key words: Anti depressive action, Sedative, Voltage gated calcium channel, Alprazolam, Imipramine.

STUDY ON EXPLORATION OF EFFECT OF VOLTAGE GATED CALCIUM CHANNEL BLOCKERS ON THE ANTI DEPRESSANT ACTION OF IMIPRAMINE AND ALPRAZOLAM