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The object of the present study is to develop sustained release system of the antihistaminic agent Chlorpheniramine maleate generally used in allergic disorders, asthama, common cold and other conditions.  Matrix tablet is one of the least complicated devices to sustain the release of drug candidates. Different grades of polymers HPMC viz HPMCK4M and HPMCK15M were selected to sustain the release up to 12 hrs. Optimization techniques using factorial design for two factors at three levels (3 2 ) was selected to optimize varied response variables viz. release rate exponent (n), t50%, k, amount of drug released in 12h (Rel12h) and mean dissolution time MDT.  The optimum formulations were selected and the results obtained with the experimental values were compared with the predicted values. In conclusion, the results suggest that the developed sustained-release matrix tablets could provide quite regulated release of Chlorpheniramine maleate up to nearly 12 hr.

Formulation of Sustained Release Chlorpheniramine maleate Matrix Tablets through Optimization and their Evaluation.