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The emergence of antibiotic resistance in bacteria is threatening as in case of Staphylococcus aureus and is well known for causing nosocomial infections in humans. In this study a total of 50 isolates of S.aureus were isolated from clinical samples collected from wound, boils, abscesses, ulcers and post operative infections (POI). The isolate exhibiting multi-antibiotic resistance was subjected for test of synergism. Synergism can be best achieved by checkerboard or Fractional Inhibitory Concentration (FIC). A combination of ampicillin and kanamycin were used for the checkerboard method. From the checkerboard, the MIC of ampicillin and kanamycin alone were 160µg/ml and 80µg/ml respectively. However a combination of both antibiotics required were just 10µg/ml and 20µg/ml of ampicillin and kanamycin with a FIC index of 0.562 indicating their synergistic effect. Thus from this study it can be concluded that antibiotic combination therapy is the best way to achieve synergy when the causal organism is a multi-antibiotic resistant one. Key words: Staphylococcus aureus, Antibiotic resistance, Checker board and Synergy test.

EVALUATION OF IN VITRO SYNERGY BETWEEN AMIPICILLIN AND KANAMYCIN AGAINST STAPHYLOCOCCUS AUREUS