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Objective: To evaluate the Antidiabetic & Antihyperlipidemic effect of Centratherum Anthelminticum (L) Kuntze extract against STZ induced diabetic rats. Methods: The present study examined the influence of Centratherum Anthelminticum extract (CASE), on blood glucose level and antioxidant enzymes level in STZ induced diabetic rats. The possible effects of chronic administration of the extract on the fasting serum glucose, insulin, and total cholesterol and triglycerides levels in STZ-induced diabetic rats were also evaluated. Results: The extracts showed a marked Antidiabetic & Antihyperlipidemic effect. Centratherum anthelminticum ethanolic seeds extract is capable of exhibiting glycemic control through its inhibitory effect on glycogenolytic enzyme glycogen phosphorylase, gluconeogenic enzymes such as glucose-6-phosphatase and fructose-1, 6-bis phosphatase and stimulatory effect on hexokinase, which is the key enzyme in the glycolytic pathway. Antihyperlipidemic activity of Centratherum anthelminticum ethanolic seeds extract proved by restoration of altered lipid profile Conclusions: The results of the study indicate that the extract of Centratherum anthelminticum possesses strong antidiabetic & antihyperlipidemic activity. This study also describes therapeutic effect of Centratherum anthelminticum in diabetes which will give a new direction for the future scientific research.

journal of drug delivery and therapeutics

Evaluation of Antidiabetic and Antihyperlipidemic Effect of Ethanolic Leaves Extract of Centratherum anthelminticum (L) Kuntze against STZ Induced Diabetic Rats