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Objectives: The current investigation was conducted to examine the ability of ethanolic extract from onion dayak (Eleutherine palmifolia) (L) (Merr) tuber to reduce blood glucose and increase insulin production in streptozotocin-induced diabetic wistar rat. Materials and Methods: Extraction was accomplished using maceration method with 96% ethanol. Antidiabetic activity was evaluated using observation of blood glucose levels utilize glucometer (Easy Touch). Analysis of insulin plasma concentration was determined utilize the Insulin Elisa Kit (Chem Cruz). Results: The administration of dayak onion extract as a form of therapy in diabetes, although it has not been able to increase insulin levels significantly, but has shown a tendency to increase insulin levels at higher doses of 500 mg/bw. Conclusion: Ethanolic extract from dayak onion tuber exhibited activity of decrease blood glucose level and increase plasma insulin concentration in streptozotocin-induced diabetic wistar rat.

asian journal of pharmaceutical research and development

THE EFFECT OF ETHANOLIC EXTRACT OF DAYAK ONION (Eleutherine palmifolia (L) MERR) TUBER ON BLOOD GLUCOSE AND INSULIN LEVEL OF STREPTOZOTOCIN-INDUCED DIABETIC WISTAR RAT