English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A new, simple, selective, precise and accurate spectrophotometric method for the determination of metformin in pharmaceutical formulation was developed and validated. The method was based on the reaction between metformin and 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) at alkaline medium (pH 12.0) to form brown adduct. Beer’s law was obeyed in the concentration range of 20-100 μg mL of metformin at maximum wave length 465 nm . Under the optimized reaction conditions, the linear regression equation of the calibration curve was found to be y=0.003x +0.156 with a linear correlation coefficient (r=0.999). The limit of detection (LOD) and limit of quantification (LOQ) were found to be 5.8, 17.5 μg mL respectively. The method is useful for routine analysis of metformin in quality control laboratories.

asian journal of pharmaceutical research and development

Utilization of 4-Chloro-7-Nittobenzo-2-Oxa-1, 3-Diazol (NBD-CL) as Chromogenic Reagent for Determination of Metformin hydrochloride (MET) in Pharmaceutical Formulation