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Differential expression of the C-X-C Motif Chemokine Ligand 12 (CXCL12) between the M and NM OMMs suggests that canine OMM metastasis is mediated by interaction between CXCL12and CXCR4. Increased expression of Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3A (APOBEC3A) in the M OMMs may be indicative of APOBEC3A-induced double-strand DNA breaks and pro-metastatic APOBEC3A-mediated hypermutation. DNA double strand breakage triggers activation of the DNA damage response network and two members of the Falconi anaemia DNA repair pathway show elevated expression in the M OMMs. RT-qPCR analysis validated the greater than two-fold differences in expression between M and NM OMMs observed for 3 genes (APOBEC3A, CXCL12and RPL29). A Linear Discriminant Analysis classifier featuring the 3 genes was estimated to categorise M OMMs as metastasising with an accuracy of 94% and NM OMMs as nonmetastasising with an accuracy of 86%.

Correlation between BRAF variant V595E and histological grade in canine transitional cell carcinoma