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The FAST ‘seizure-prone’ rat strain has been a valuable tool in the study epilepsy over the past decades, recently it has been suggested that these animals may also display the behavioral characteristics of attention-deficit hyperactivity disorder (ADHD). The present study seeks to provide evidence suggesting the FAST rats as a model for ADHD. In order to suggest any animal model a validation criterion must first be met. In the current study the validation of the suggested animal model is carried out through the development of a novel behavioral paradigm. The test was designed to encompass a measure for each of the defining characteristics of ADHD, that being inattention, hyperactivity, and impulsivity. The current study sought to accomplish two main goals a) provide evidence that shows the ADHD characteristics of the FAST rats and b) validate the behavioral test as a reliable measure for ADHD in an animal. The conclusions from the present study clearly display a higher activity level of the FAST rat when compared to the SLOW rats, however measures of attention failed to present any significant results. Furthermore, the tests of impulsivity were not performed as a result of the fact that the animals both FAST and SLOW failed to learn the task in a manner that would have allowed these measures to be realized. Although the presented data shows the hyperactive nature of the FAST rats, hyperactivity alone does not warrant a diagnosis of ADHD, the failure of the behavioral test to accurately assess the defining characteristics of ADHD suggests that further validation of the FAST rats as a model of ADHD requires the use of previously established measures of hyperactivity, inattention and hyperactivity. R eproduced with perm ission of the copyright owner. Further reproduction prohibited without perm ission.

The FAST "Seizure-prone" rat strains; as a possible animal model of attention-deficit hyperactivity disorder (ADHD)