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Localization of growth hormone-releasing hormone (GHRH) in normal human pancreas was examined immunohistochemically with four different anti-GHRH sera. Antisera raised aginst synthetic human GHRH(1-40)OH and GHRH(1-29)Glyi-Cys-NH2 gave no positive immunoreaction. Two other antisera (RGl07 and #4676) raised against synthetic human GHRH(1—44)NH2 reveal GHRH-like immunoreactivity in pancreatic polypeptide (PP) cells, but the iminunoreactivity was abolished when RGIO7 or #4676 was absorbed by synthetic human PP(1—5’6)NH2. Among sixteen pancreatic endocrine tumors, only one tumor from an acromegalic patient contained many cells that reacted with all four anti-GHRH sera; this immunoreactivity disappeared by the addition of synthetic GHRH(1-44)NH2 but not of PP(1-36)NH2. The remaining fifteen tumors, which included eleven PP-positive tumors, did not show any immunoreactivity against the four anti-GHRH sera. The findings suggest that the anti-GHRH-44 sera (RGl07 and #4676) contain not only an antibody for GHRH but also antibody that recognizes PP or an antibody that recognizes both GHRH and PP, and also that cells with genuine GHRH immunoreactivity are absent in normal human pancreas. In addition, it is suggested that the molecular structure of PP in normal pancreas differs from that in pancreatic endocrine tumors. Since growth hormone-releasing hormone (GHRH) was first isolated from human pancreatic tumor (6, ll), localization of GHRH in normal human tissues has been investigated. Although the pancreas has received special attention by many investigators, results are conflicting, with respect to the presence of GHRH in this organ. By radioimmunoassay, Yamaguchi er al. (18) could not detect any immunoreactive GHRH in normal pancreas, whereas Shibasaki er al. (l6) found it in a large amount. Immunohistochemically, Asa er al. (l), Bostwick er ai. (3) and Dayal er al. (4) did not find any GHRH-immunoreactive cells, but Bosman er al. (2) observed GHRH-immunoreactivity in pancreatic polypeptide (PP) cells.

biomedical research

&lt;b&gt;IMMUNOREACTIVITY AGAINST ANTI-GROWTH HORMONERELEASING HORMONE (GHRH) SERA IN HUMAN PANCREAS AND PANCREATIC ENDOCRINE TUMORS: EVIDENCE OF PITFALL IN IMMUNOHISTOCHEMICAL &lt;/b&gt;&lt;b&gt;STUDY &lt;/b&gt;