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The cerebellar vermis defect (cvd) rat is a mutant characterized by a cerebellar vermis defect and fused cerebellar hemisphere. This mutant rat also exhibits heterotopic dysplastic cerebellum, especially in the cerebello-pontine junctional zone. We focused on the auditory system of the cvd rat. The homozygous cvd rats exhibited bilaterally indistinct ABR (auditory brainstem response) waves or prolongation of latency in each ABR component. The number of the spiral ganglion neurons in the Rosenthal's canal was apparently decreased in the homozygous rats. Present study indicates the homozygous cvd rats had auditory disorders concerned with cerebellar malformation.

Auditory Disorder in the Cerebellar Vermis Defect (cvd) Rats