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The neurotoxic property of kainic acid was exploited in an investigation of neuronal projections from the rat hippocampus. Extraand intrahippocampal projections from the pyramidal cells of area CA3 of the dorsal hippocampus were identified after selective destruction of the pyramidal cells by an intraventricular injection of kainic acid. Subsequent silver impregnation using the Fink-Heimer method showed mainly that the dorsal part of the bilateral lateral septal nucleus, the bilateral cingular gyri and the bilateral subicular area were extrahippocampal projection sites, and that the stratum oriens of areas CA1, CA2 and CA3 of the bilateral dorsal and caudal hippocampus together with the stratum radiatum of area CA1 of the ipsilateral dorsal hippocampus were intrahippocampal projection sites.

biomedical research

&lt;b&gt;Application of kainic acid to the detection of neuronal projections from area CA3 of the dorsal hippocampus of the &lt;/b&gt;&lt;b&gt;rat &lt;/b&gt;