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The LD50 values for calcium chloride in F3 adult male and female rats raised from mothers parathyroidectomized on the 15th day of pregnancy (l5d-PTx) were much lower than in normal adult rats. Parathyroidectomy on the 5th day of pregnancy (5d-PTX) failed to induce the hypersensitivity to a lethal dose of calcium in the F3 rats. Despite the low LD50 values for calcium chloride in the 15d-PTx F3 rats, their serum calcium level at 1.5-2 min after the injection of calcium solution did not differ from the levels in normal and 5Cl—PTX F3 rats.

Hypersensitivity to lethal effect of injected calcium chloride in the third generation rats raised from parathyroidectomized mothers