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This is a family of 5 evolutionarily related proteins. Their structural similarities suggest that they are transporters. Biochemical evidence supports transporter activity for SLC66A1 (LAAT1) and SLC66A4 (CTNS; Cystinosin). The functions of the 3 remaining members of the family are undetermined.

SLC66 Lysosomal amino acid transporters (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database