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Since prominent role in valproate metabolism is assigned to CYP2C9 in pediatric patients, the association between children's CYP2C9-status and serum valproate concentrations or dose-requirements was evaluated.

Phenoconversion of CYP2C9 in Epilepsy Limits the Predictive Value of CYP2C9 Genotype in Optimizing Valproate Therapy