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In the AIEOP-BFM 2000 trial, 15% of pediatric patients treated according to risk-adapted polychemotherapeutic regimens relapsed. The present study aimed to investigate the influence of GST-M1 and GST-T1 deletions on clinical outcome of children with acute lymphoblastic leukemia treated according to the AIEOP-BFM ALL 2000 study protocol.

pharmacogenomics

Glutathione <i>S</i> -Transferase Homozygous Deletions and Relapse in Childhood acute Lymphoblastic Leukemia: a Novel Study Design in a Large Italian AIEOP Cohort

Glutathione S -Transferase Homozygous Deletions and Relapse in Childhood acute Lymphoblastic Leukemia: a Novel Study Design in a Large Italian AIEOP Cohort