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First, evaluate if patients carrying putatively diminished activity CYP2C8 genotype have longer paclitaxel exposure (e.g., time above threshold concentration of 0.05 μM [T c &gt;0.05 ]). Second, screen additional pharmacogenes for associations with T c &gt;0.05 . Methods: Pharmacogene panel genotypes were translated into genetic phenotypes for associations with T c &gt;0.05 (n = 58).

Patients carrying CYP2C8*3 have shorter systemic paclitaxel exposure

Patients carrying CYP2C83* have shorter systemic paclitaxel exposure