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Receptor-specific small molecules and nanoparticles are widely used in molecular imaging of tumors. Although some studies have described the relative strengths and weaknesses of the two approaches, reports of a direct comparison and analysis of the two strategies are lacking. Herein, we compared the tumor-targeting characteristics of a small near-infrared fluorescent compound (cypate-peptide conjugate) and relatively large perfluorocarbon-based nanoparticles (250 nm diameter) for imaging alpha(nu)beta(3)-integrin receptor expression in tumors.

Targeting of ανβ3-integrins expressed on tumor tissue and neovasculature using fluorescent small molecules and nanoparticles

Targeting of α_νβ₃-integrins expressed on tumor tissue and neovasculature using fluorescent small molecules and nanoparticles