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Objective: The objective of this research was to synthesize and evaluate anti-microbial properties of 1-(6-nitro-2 H -benzo[ b ][1,4]thiazine-3(4 H )-ylidene)hydrazine-1,1-dioxide derivatives. Methods: These new compounds were synthesized by reaction of 2 H -benzo[b][1,4]thiazin-3(4 H )-one with hydrazine derivatives and oxidized at the sulfur atom by 30% hydrogen peroxide to obtain sulfones. All the synthesized compounds were evaluated for antimicrobial activity using the disc diffusion method. Results: The FTIR, 1 HNMR, 13 CNMR and Mass studies confirms the synthesis of some new 1-(6-nitro-2 H -benzo[ b ][1,4]thiazine-3(4 H )-ylidene) hydrazine-1,1-dioxide derivatives. Compound 5f showed potent antimicrobial activity whereas compounds 5c and 5e showed moderate antimicrobial activity. Conclusion: Result obtained in this research work clearly indicated that the compound 5f having methyl at 2 position and nitro groups at 2′ and 4′ position showed the most potent antimicrobial activity.

SYNTHESIS AND ANTI-MICROBIAL ACTIVITY OF 1-(6-NITRO-2H-BENZO[b][1,4]THIAZINE-3(4H)-YLIDENE)HYDRAZINE-1,1-DIOXIDE DERIVATIVES