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Objective: This cross-sectional study was designed to correlate the expression of mRNA and protein of (pro)renin receptor ([P]RR) and vascular endothelial growth factor (VEGF) gene in preeclampsia placentas. Methods: We used 34 placenta tissues of normal pregnancy and 34 preeclampsia placenta tissues. Real-time polymerase chain reaction was used to measure relative expression of VEGF and (P)RR mRNAs, and protein concentration was measured using Sandwich ELISA technique. Results: VEGF mRNA relative expression of preeclampsia placenta was 2.83 times higher than the normal placenta (p=0.02). (P)RR mRNA relative expression on preeclampsia placenta was 1.7 times higher than the normal one (p=0.039). Expression of protein (P)RR and VEGF was lower on preeclampsia shown by p<0.05, R=0.441. From this research, it was considered that low protein of (P)RR and VEGF contributes to preeclampsia. Conclusion: There was a correlation between (P)RR and VEGF. It considers that there is any involvement of (P)RR on angiogenesis through VEGF expression in preeclampsia placenta.

CORRELATION OF (PRO)RENIN RECEPTOR AND VASCULAR ENDOTHELIAL GROWTH FACTOR EXPRESSION LEVEL IN THIRD TRIMESTER OF PREECLAMPSIA PLACENTAS