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Objective: As an antiobesity therapy, combination extracts of Detam 1 soybean and Jati Belanda will be consumed for a long time; therefore, their toxicities to the liver need to be investigated. To determine the effect of subchronic toxicity test of combination of ethanol extract of Detam 1 soybean (EEDS) and ethanol extract of Jati Belanda (EEJB) on liver function with parameters: Alanine transaminase (ALT), macroscopic, and histopathological of liver. Methods: This study was conducted on 120 Wistar rats (60 males and 60 females), 90 days (treatment group) and 120 days (satellite group). Rats were divided into six treatment groups (3 test materials, 1 control, and 2 satellites); each group included 10 males and 10 females. Results: ALT levels of treatment groups (low dose, medium, and high), both males and females were lower than the control group (p 0.05). Results of histopathological score interpretation of male and female liver rats of low dose groups were not disturbed; middle dose groups were slightly disturbed and high dose groups were damaged. Satellite high doses of male groups were disrupted, while female groups were not. Conclusion: The combination of EEDS and EEJB has a good effect on liver function, did not lead to change organ weight and at low doses did not cause renal histopathology damage in rats after 90 days administration. Keywords: Combination of soybean Jati Belanda, Toxicity subchronic test, Function, Weight, Histopathology, Liver.

asian journal of pharmaceutical and clinical research

SUBCHRONIC TOXICITY TEST OF COMBINATION ETHANOL EXTRACT OF DETAM 1 SOYBEAN (GLYCINE MAX L. MERR) AND JATI BELANDA (GUAZUMA ULMIFOLIA LAMK) TOWARD FUNCTION, WEIGHT, AND HISTOPATHOLOGICAL OF WISTAR RAT LIVER