Open AccessPharmacokinetics and Pharmacodynamics of Piperacillin-Tazobactam in 42 Patients Treated with Concomitant CRRT
Author(s) -
Seth R. Bauer,
Charbel Salem,
Michael Connor,
Joseph J. Groszek,
Maria E. Taylor,
Peilin Wei,
Ashita J. Tolwani,
William H. Fissell
Publication year - 2012
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.10741011
Subject(s) - medicine , renal replacement therapy , piperacillin , piperacillin/tazobactam , tazobactam , pharmacokinetics , pharmacodynamics , dosing , concomitant , volume of distribution , renal function , intensive care medicine , biology , bacteria , pseudomonas aeruginosa , genetics
Current recommendations for piperacillin-tazobactam dosing in patients receiving continuous renal replacement therapy originate from studies with relatively few patients and lower continuous renal replacement therapy doses than commonly used today. This study measured the pharmacokinetic and pharmacodynamic characteristics of piperacillin-tazobactam in patients treated with continuous renal replacement therapy using contemporary equipment and prescriptions.
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