Open Accessp-Cresyl Sulfate and Indoxyl Sulfate in Hemodialysis Patients
Author(s) -
Björn Meijers,
Henriëtte de Loor,
Bert Bammens,
Kristin Verbeke,
Yves Vanrenterghem,
Pieter Evenepoel
Publication year - 2009
Publication title -
clinical journal of the american society of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.755
H-Index - 151
eISSN - 1555-905X
pISSN - 1555-9041
DOI - 10.2215/cjn.02940509
Subject(s) - sulfate , cresyl violet , chemistry , albumin , hemodialysis , biochemistry , medicine , pharmacology , endocrinology , chromatography , pathology , staining , organic chemistry
Indoxyl sulfate and p-cresyl sulfate are important representatives of the protein-bound uremic retention solutes. Serum levels of p-cresyl sulfate and indoxyl sulfate are linked to cardiovascular outcomes and chronic kidney disease progression, respectively. They share important features such as the albumin-binding site, low dialytic clearance, and both originate from protein fermentation. Whether serum concentrations are related is, however, not known.
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