Open AccessIV Administered Gadodiamide Enters the Lumen of the Prostatic Glands: X-Ray Fluorescence Microscopy Examination of a Mouse Model
Author(s) -
Devkumar Mustafi,
Sophie-Charlotte Gleber,
Jesse Ward,
Urszula Dougherty,
Marta Zamora,
Erica Markiewicz,
David Binder,
Tatjana Antic,
Stefan Vogt,
Aytekin Oto
Publication year - 2015
Publication title -
american journal of roentgenology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.294
H-Index - 196
eISSN - 1546-3141
pISSN - 0361-803X
DOI - 10.2214/ajr.14.14055
Subject(s) - medicine , gadodiamide , lumen (anatomy) , pathology , x ray , microscopy , fluorescence microscope , anatomy , nuclear medicine , radiology , fluorescence , magnetic resonance imaging , surgery , optics , physics
Dynamic contrast-enhanced MRI (DCE-MRI) has become a standard component of multiparametric protocols for MRI examination of the prostate, and its use is incorporated into current guidelines for prostate MRI examination. Analysis of DCE-MRI data for the prostate is usually based on the distribution of gadolinium-based agents, such as gadodiamide, into two well-mixed compartments, and it assumes that gadodiamide does not enter into the glandular lumen. However, this assumption has not been directly tested. The purpose of this study was to use x-ray fluorescence microscopy (XFM) imaging in situ to measure the concentration of gadodiamide in the epithelia and lumens of the prostate of healthy mice after IV injection of the contrast agent.