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We investigated the interactions between Thioredoxin (Trx) and BNP7787 (Tavocept®). BNP7787 is a water-soluble disulfide that appears well-tolerated and nontoxic, and in separate randomized multicenter Phase 2 and Phase 3 clinical trials in NSCLC patients, BNP7787 in combination with standard chemotherapy, resulted in substantial increases in the overall survival of patients with advanced adenocarcinoma

BNP7787 Forms Novel Covalent Adducts on Human Thioredoxin and Modulates Thioredoxin Activity