English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

BACKGROUND AND OBJECTIVE: Acetaminophen can induce liver damage via oxidative stress. This study aimed to evaluate the protective effects of fenugreek seed powder on oxidant and antioxidant factors in acetaminophen-induced liver toxicity. .METHODS: In this experimental study, 24 male Wistar rats, weighing 250-280 g, were divided into four groups: control, normal saline+fenugreek seed powder, acetaminophen and acetaminophen+fenugreek seed powder. After 24 h of fasting, groups Normal and Normal+ Fenugreek received normal saline and groups Acetaminophen and Acetaminophen + Fenugreek received 1000 mg/kg acetaminophen by gavage. After six hours, the normal saline and acetaminophen groups received normal saline, whereas the groups receiving normal saline+fenugreek powder and acetaminophen+fenugreek powder were administered 1000 mg/kg of fenugreek seed powder via gavage. Twelve hours after the second gavage, the rats were sacrificed and liver tissues were frozen and assessed. FINDINGS A decline in malondialdehyde and hydrogen peroxide levels was observed in group acetaminophen+fenugreek, compared to the acetaminophen group (0.2608±0.03 and 1.56±0.153 vs. 6.7±0.344 and 2.38±0.104 in acetaminophen groups; p<0.001 and p<0.05, respectively). Also, the activities of peroxidase and catalase increased in these groups, compared to the acetaminophen groups (19.07± 3.366 and 1.174±0.242 vs. 8.108 ± 2.46 and 0.614±0.089 in acetaminophen groups, respectively). CONCLUSION: The results of this study showed that fenugreek seeds could lead to reduced oxidative stress in acetaminophen-induced liver toxicity

The Effects of Fenugreek Seed Powder on Oxidant and Antioxidant Factors in Male Rats with Acetaminophen-induced Liver Toxicity