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An international workshop on the Integration of Deep Biosphere Research into the International Continental Scientific Drilling Program (ICDP) was held on 27–29 September 2009 in Potsdam. It was organized by the Helmholtz Centre Potsdam GFZ German Research Centrefor Geosciences and the University of Potsdam (Germany). Financial support was provided by ICDP. This workshop brought together the expertise of thirty-three microbiologists, biogeochemists, and geologists from seven countries (Finland, Germany, Japan, New Zealand, Sweden, U.K., U.S.A.). Over the last two decades, microbiological and biogeochemical investigations have demonstrated the occurrence of microbial life widely disseminated within the deep subsurface of the Earth (Fredrickson and Onstott, 1996; Parkes et al., 2000; Pedersen, 2000; Sherwood Lollar et al., 2006). Considering the large subsurface pore space available as a life habitat, it has been estimated that the biomass of the so-called deep biosphere might be equal to or even larger than that of the surface biosphere (Whitman et al., 1998)