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Objective(s) Diabetes related dysfunction of resistance vessels is associated with vascular occlusive diseases. Vasorelaxant agents may have a role in control of diabetic cardiovascular complications. Gamma aminobutyric acid (GABA) has demonstrated to cause vasorelaxation. The present study was designed to determine i) the vasorelaxatory effect of GABA on diabetic vessels and ii) the role of endothelium in GABAinduced vasorelaxation. Materials and Methods After Diabetes induction,. Mesenteric arteries of animals were perfused. Vascular beds were constricted with phenylephrine. GABA (1 to 50 µM) was added into the medium and perfusion pressure was then recorded. Results

Relaxatory Effect of Gamma-Aminobutyric Acid (GABA) is Mediated by Same Pathway in Diabetic and Normal Rat Mesenteric Bed vessel