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The degradation behavior of Silk Fibroin (SF) by elastase was investigated. The inhibitory effects of the hydrolyzed solution on ?-glucosidase were also examined. Elastase follows MichaelisMenten kinetics with Km and Vm values of 14.49 mg/ml and 1.96 ?mol/min, respectively, and the SF peptides with Km and Ki values of 3.8 mg/ml and 3.55 mg/ml. The inhibition effect of the peptide solution on ?-glucosidase was found to be noncompetitive and reversible. The hydrolyzed fragments with molecular weights under 6 kDa exerted the prominent inhibiting effect on mice ?-glucosidase, with the inhibition activity of 36.6  38.9%. These results suggested that SF peptides might exert anti-diabetic effect by suppressing carbohydrate absorption from the intestine, and thereby decrease the postprandial increase of blood glucose.

Enzyme Hydrolysis of Silk Fibroin and the Anti-diabetic Activity of the Hydrolysates