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The effect of electromagnetic manipulation (EM), consisting of an oscillating (50 Hz) high electrical potential (a maximum value of 20,000 V and an output current &lt; 100 µA) and its associated alternating magnetic field (50-60 Guass), on the hepatoprotective action of schisandrin B (Sch B, an active ingredient isolated from the fruit of Schisandra chinensis) was examined in the mouse model of carbon tetrachloride (CCl4) hepatotoxicity and the AML12 cell model of menadione-induced toxicity. EM was found to enhance the Sch B-induced hepatoprotective action against CCl4 toxicity in mice and cytoprotective action against menadione toxicity in AML12 hepatocytes. The potentiating effect of EM on the pharmacological action of Sch B may be mediated by the increase in drug availability to tissues or cells and/or the pro-oxidant action of electromagnetic field in vivo.

journal of complementary and integrative medicine

Exposure to Oscillating High Electrical Potential and the Associated Low Frequency Magnetic Field Enhances the Hepatoprotective Action of Schisandrin B in Vivo and in Vitro