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The present investigation studied the interaction of the aqueous extract of Pleurotus pulmonarius (Fr.) Quel.-Champ (Lentinacae) (called PP-aqu) with metformin on serum glucose level, body weight and oral glucose tolerance test (OGTT) in alloxan-induced diabetes in mice. PP-aqu (500 mg/kg), metformin (250 and 500 mg/kg) singly and concomitantly were administered orally in alloxan-induced (70 mg/kg, i.v.) diabetic mice. In the acute study, serum glucose levels were determined at 0, 2, 4, 6 and 24 h after drug administration. The sub-acute study involved repeated administration of drugs for 14 days. In OGTT, D-glucose (2.5 g/kg) was administered in diabetic mice 30 min after pretreatment with PP-aqu (500 mg/kg), metformin (250 and 500 mg/kg) and their concomitant administration. The onset and peak antihyperglycaemic effect of PP-aqu (500 mg/kg) and metformin (250, 500 mg/kg) alone was 2 h. Onset of concomitant administration of PP-aqu (500 mg/kg) with metformin (250 and 500 mg/kg) was 2 h; the peak effect was 6 h and the duration of action was 24 h. Repeated administration (once a day for 14 days) of metformin, PP-aqu and their concomitant administration caused significant (P&lt;0.001) reduction in the serum glucose level as compared to vehicle treated group. Concomitant treatment prevented decrease in body weight of diabetic mice. In OGTT, concomitant administration of PP-aqu with metformin increased glucose threshold. The concomitant administration of PP-aqu with metformin produced synergistic antihyperglycaemic effect than either drug alone.

Effect of Concomitant Administration of Aqueous Extract of Pleurotus pulmonarius and Metformin in Diabetic Mice