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Nagamine and Ohkuma reported the presence of alkaline phosphatase-liked immunoglobulin G in the serum of a patient with multiple epiphyseal dysplasia in 1975.1) Since that time, numerous studies have dealt with alkaline phosphatase-immunoglobulin complexes (ALP-Ig). The heterogeneous molecular weight of these complexes have been described as 550kD,2) 280kD,3) 500kD4) or 900kD.5) These results have been discussed from the view that the complex consisted of one or more enzymes against one immunoglobulin molecule. On the other hand, some immunoglobulins which associated with the complexes of serum enzyme and immunoglobulin have been considered as autoantibodies.6,7) In such cases, these complexes have been accepted as immune complexes. Fragments of complement component C3, such as C3c and/or C3d bind to many kinds of immune complexes, and many circulating immune complexes carry these fragments.8,9) Therefore, ALPIg may bind other substances such as complement components. In the present study, ALP-Ig from two patients were analyzed by counterimmunoelectrophoresis using anti-human antibodies, in order to determine the association of complement components.

Comparison of molecular weight of two cases of alkaline phosphatase-immunoglobulin G complexes in relation to complement fragment C3c.