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Back ground: Acromegaly is a rare endocrine disease; its incidence is 4-6 million per year, while its prevalence is 40-60 million per year. They are separating acromegaly from gigantism that occurs before growth plates are closed. Neopterin is a systemic adaptive immune activation biomarker produced upon interferon-gamma (IFN-γ) stimulation by monocyte-derived macrophages and dendritic cells. Eighty acromegalic patients (50% diabetic acromegalic and 50% nondiabetic acromegalic) and forty healthy control groups were enrolled in the study to find out the level of Neopterin and insulin-like growth factor-1 in the sera of the study population; the results showed both molecules (neopterin and Insulin-like growth factor-1 were found to be high in acromegalic subjects when there is concomitant diabetes, and insulin-like growth factor-1 correlates positively with total cholesterol and neopterin. At the same time, neopterin correlates positively with HbA1c. This study was aimed to find out the difference in neopterin level in diabetic acromegalic versus n0n-diabetic acromegalic patients;Eighty acromegalic subjects were enrolled in across sectional study by measuring the neopterin level in the sera of diabetics and nondiabetics as 39 have diabetes while the remaining 41 patients are nondiabetic. Neopterin is high among diabetic acromegalic patients when compared with nondiabetic acromegalic subjects. Insulin-like growth factor-1 correlates positively with neopterin and total cholesterol; (4) Conclusions: Across sectional-study enrolling eighty acromegalic patients registered in the National Diabetes Center. Thus they were subdivided into two groups: - diabetic and nondiabetic the level of neopterin was found to be among diabetic versus nondiabetics.

The presence of Neopterin in the sera of a sample of Iraqi acromegalic patients (Type 2 diabetics and nondiabetics)