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Among the different models developed to understand the biology of inflammation in ulcerative colitis (UC), the model of colitis induced by Dextran sulfate Sodium (DSS) is the most used because of its simplicity, its cost effectiveness and similarity with ulcerative colitis in humans. It ́s known that DSS can change the expression of some genes. The aim of this work is to know the changes in the expression profile of Ulcerative Colitis Disease (UCD) related genes in the colon of rats treated for 5 days with 8% DSS, in order to better characterize this model. The workflow consisted in the biopsy collection from distal colon, followed by total RNA extraction and analysis of gene expression by quantitative RT-PCR (qPCR) of 55 genes related to inflammation, epithelial integrity, oxidative stress, as well as proliferation and differentiation cellular. Sixty percent of the analyzed genes change their expression with statistically significance, 5 genes were upregulates and 28 genes were downregulates. The upregulates genes are related with inflammation and oxidative stress. The downregulates genes are related with the integrity of the epithelial barrier and also with cellular proliferation and differentiation, both process involved in the intestinal epithelial renovation. These results support the use of this animal model in the development of new drugs against ulcerative colitis.

Pharmacogenomic assessment of an acute colitis model