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A new type of surface modification of multichannel silicon-on insulator based sensors was proposed, including the use of a bifunctional reagent carbonyldiimidazole for the formation of a interface layer instead of modified silanes, and troponine probes for specific detection of fragments of the troponin template RNA (analyte) as a marker of a heart attack myocardium. Impact of glycine and aminoethanol passivation of carbonyldiimidazoleactivated surface of sensors at the final stage of modification (before applying the analyte) on the response of the sensors and the background signal level was studied. It was shown that at a picomolar concentration of an analyte, the proposed type of surface modification with treatment in glycine provides a highly specific response of ∼ 60%. Different mechanisms are responsible for the increase in response and specificity of the sensors at detection of the analyte after passivation with glycine and aminoethanol. Физика и техника полупроводников, 2020, том 54, вып. 4

Модификация поверхности КНИ-сенсоров для детекции РНК-биомаркеров