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In recent years, an elevated serum alpha 1-antichimotrypsin (ACT) levels is associated with increased risk of Alzheimer-type dementia. The relationship between ACT and conventional various cardiovascular risk factors were studied using 589 noninstitutionalized individuals aged 65 and older living in the community in Japan. Serum ACT levels had no significantly differences between men and women, and had no significantly association with age in both sexes. Serum ACT levels had no statistically significant associated with body mass index, blood pressure, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol in both sexes. There were no significant differences in mean of serum ACT levels between in subjects with prevalent and subclinical cardiovascular disease and in those who were free of disease. A prospective study design is needed to clarify the relation between ACT and the development of Alzheimer-type dementia.

Serum α 1-Antichimotrypsin Levels and Cardiovasucular Risk Factors in the Japanese Elderly Population: