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Some case-control association studies revealed the relationship between some endothelin-1 (ET-1) gene polymorphisms and blood pressure. Because no report was available about the relationship between any ET-1 gene polymorphism and incidence of hypertension, we examined the relationship between novel ET-1 gene polymorphism (G862T / Ala288Ser in exon 5) and incidence of hypertension by a retrospective cohort study.

journal of epidemiology

The Lack of Relationship between an Endothelin-1 Gene Polymorphism (Ala288Ser) and Incidence of Hypertension: A Retrospective Cohort Study among Japanese Workers