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Tumor cell destruction by boron neutron capture therapy (BNCT) is attributed to the nuclear reaction between 10 B and thermal neutrons. The accumulation of 10 B atoms in tumor cells without affecting adjacent healthy cells is crucial for effective BNCT. We previously reported that several types of liposomal boron delivery systems (BDS) delivered effective numbers of boron atoms to cancer tissues, and showed tumor-growth suppression after thermal neutron irradiation. In the present study, we examined the effects of BNCT after intra-arterial infusion of 10 B-borono-dodecaborate ( 10 BSH) by liposomal BDS in rabbit hepatic cancer models.

Suppression of Tumor Growth in a Rabbit Hepatic Cancer Model by Boron Neutron Capture Therapy With Liposomal Boron Delivery Systems