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The hormonally-active form of vitamin D, 1,25(OH) 2 D 3 , demonstrated activity against oral squamous cell carcinoma (OSCC). Cytochrome P450scc (CYP11A1)-derived vitamin D hydroxyderivatives, such as 20(OH)D 3 and 1,20(OH) 2 D 3 , have overlapping beneficial effects with 1,25(OH) 2 D 3 without causing hypercalcemia. This study sought to determine (i) whether 20(OH)D 3 and 1,20(OH) 2 D 3 exhibit antitumor effects against OSCC comparable to those of 1,25(OH) 2 D 3 and (ii) whether these effects may stem from down-regulation of sonic hedgehog (SHH) or WNT/β-catenin signaling pathways.

Noncalcemic Vitamin D Hydroxyderivatives Inhibit Human Oral Squamous Cell Carcinoma and Down-regulate Hedgehog and WNT/β-Catenin Pathways