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Breast cancer ranks second in the list of cancer-related deaths for women. Even under multidisciplinary treatment, 25-50% of patients with breast cancer still ultimately develop metastasis, leading to poor prognosis. In addition to inducing angiogenesis, vascular endothelial growth factor-A (VEGF-A) is believed to directly increase cancer cell metastatic potential and overexpression of VEGF-A is associated with higher invasiveness of breast cancer. 1α,25(OH) 2 D 3 , the active form of vitamin D, and its analogs have been widely applied as anticancer agents in the past.

MART-10, a 1α,25(OH)2D3 Analog, Potently Represses Metastasis of ER+ Breast Cancer Cells with VEGF-A Overexpression

MART-10, a 1α,25(OH)₂D₃ Analog, Potently Represses Metastasis of ER⁺ Breast Cancer Cells with VEGF-A Overexpression