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Stereotactic body radiation therapy (SBRT) is a viable treatment option for stage I non-small cell lung carcinoma (NSCLC) in non-surgical candidates. Although treatment with a 100 Gy biological effective dose is considered to carry a low risk of local recurrence, only a few reports have focused on changes in tumors or surrounding intact portions of the lung after SBRT. Such changes are assessed using diagnostic imaging specifically for radiation pneumonitis, which can be difficult to distinguish from local tumor recurrence. Cavity changes after SBRT observed around the tumor within the irradiated field resemble an egg, fried with the yolk facing upward, and are thus referred to as 'sunny-side-up egg-like' changes. They have the appearance of a residual tumor in the center. This study aimed to evaluate patients with post-treatment cavity changes after SBRT for stage I NSCLC.

anticancer research/anticancer research

Radiation Pneumonitis Changes over Time after Stereotactic Body Radiation Therapy for Lung Tumors: Post-treatment Cavity (Sunny-side-up Egg-like) Changes